Expression and role of Tie-2 in rectal carcinoma

Objective To investigate the expression of Tie-2 in rectal carcinoma and its relationship with invasion and metastasis in rectal carcinoma. Materials S-P immunohistochemical assay was used to detect the expression of Tie-2 in 40 cases of rectal carcinoma and 10 cases of normal rectal tissues. Results Tie-2 was mainly localized in the cytoplasm and nucleus of vascular endothelial cells in cancerous tissues and partly in the cytoplasm of some cancerous cells. The expression of Tie-2 in rectal carcinoma was significantly higher than that in normal rectal tissues (P<0.05); however, Tie-2 expression was not associated with differentiation, invasion depth and Dukes stage (P>0.05), but with lymphatic metastasis (P<0.05). Conclusion Tie-2 plays a key role in carcinogenesis and lymph node metastasis of rectal carcinoma.

作 者： Zhen-Hua Ma Kang Wang Mao Zhang Wei-Hua Shang   作者單位： Department of General Surgery, the First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710061, China  刊 名： 西安交通大學(xué)學(xué)報（英文版）  英文刊名： ACADEMIC JOURNAL OF XI'AN JIAOTONG UNIVERSITY(ENGLISH EDITION)  年，卷(期)： 2010 22(1)  分類號： U4  關(guān)鍵詞： Tie-2   rectal carcinoma   immunohistochemistry  

【Expression and role of Tie-2 in rect】相關(guān)文章：

Induction of defence gene expression by oligogalacturonic acid requires increases in both cytosolic calcium and hydrogen04-26

Induction of defence gene expression by oligogalacturonic acid requires increases in both cytosolic calcium and hydrogen04-26

An evaluation of the role played by remote sensing technology following the World Trade Center attack04-27

15 CASC-Made Satellites Play Important Role In Sichuan Earthquake Relief04-26

Down-Regulated Expression of RACK1 Gene by RNA Interference Enhances Drought Tolerance in Rice04-26

Detection of CD2 expression in chicken hematogenic embryo yolk sac lymphoid cells prior to thymus genesis04-26

The Forming-Mechanism and Role of Creativity Thinking in Dry Coal Beneficiation ofCoal with Air-Dense Medium Fl uidized04-26

Role of JAK-STAT3 signaling pathway during neuronal differentiation of rat bone marrow mesenchymal stem cells04-27