Structure and function of aggrecan

Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties. It is also crucial in chondroskeletal morphogenesis during development. Aggrecan is a multimodular molecule expressed by chondrocytes. Its core protein is composed of three globular domains (Gl, G2, and G3) and a large extended region (CS) between G2 and G3 for glycosaminoglycan chain attachment. G1 comprises the amino terminus of the core protein. This domain has the same structural motif as link protein. Functionally, the G1 domain interacts with hyaluronan acid and link protein, forming stable ternary complexes in the extracellular matrix.G2 is homologous to the tandem repeats of G1 and of link protein and is involved in product processing. G3makes up the carboxyl terminus of the core protein. It enhances glycosaminoglycan modification and product secretion. Aggrecan plays an important role in mediating chondrocyte-chondrocyte and chondrocyte-matrix interactions through its ability to bind hyaluronan.

作 者： CHRIS KIANI LIWEN CHEN YAO JIONG WU ALBERT J YEE BURTON B YANG   作者單位： CHRIS KIANI,LIWEN CHEN,YAO JIONG WU,BURTON B YANG(Sunnybrook and Women's College Health Sciences Centre and Departraent of Laboratory Medicine and Pathobiology, University of Toronto, Canada)

ALBERT J YEE(Sunnybrook and Women's College Health Sciences Centre and Department of Surgeny, Faculty of Medicine, University of Toronto, Canada) 

刊 名： 細(xì)胞研究(英文版)  ISTIC SCI 英文刊名： CELL RESEARCH  年，卷(期)： 2002 12(1)  分類號： Q2  關(guān)鍵詞： Proteoglycan   chondroitin sulfate   glycosaminoglycan   G1 domain   G3 domain  

【Structure and function of aggrecan】相關(guān)文章：

Source time-function as discriminant using empirical Greens function04-27

The Function and Development of Soybean Peptides04-26

匯報工作：clear and with structure04-25

Competition and monopoly of Chinese rural groundwater market structure and&04-26

Analysis of sextupole effects on 13 function beating in the SSRF storage ring04-27

Effects of Ca on the distribution,structure and morphology of aluminum species in polyaluminum chloride04-27

A SAPO-11 Silicoaluminophosphate Molecular Sieve with Stable Crystal Structure04-27

Synthesis and Crystal Structure of Binuclear Copper(Ⅱ)Complex Containing (Dimethylaminomethyl)ferrocene04-27

Raising medium function of environmental engineering by usinglife rubbish to produce carpet turf04-27

基于Simulink/S-Function的慣性導(dǎo)航系統(tǒng)的仿真04-27